PO-04-188 PREMATURE VENTRICULAR COMPLEXES: ASSESSING BURDEN DENSITY IN A LARGE NATIONAL COHORT POPULATION TO BETTER DEFINE OPTIMAL ECG MONITORING DURATION

PVC burden frequency has been shown to correlate with the incidence of PVC-mediated cardiomyopathy. A single center study 107 patients wearing Zio monitors indicated that measurement for 24-48 hours may not reflect total burden. This aims assess density, and significance long-term monitoring in a large national cohort. The objective this is establish optimal duration ECG required accurately characterize severity other significant factors. Patients ≥5%, age ≥18 ≥13-day wear period were analyzed between June 2011 April 2022. Patient demographics reported, mean absolute error was calculated at baseline (<10 sec), 24 hours, 48 daily to14 days. Burden end considered true value measured described each subinterval (mean, SD, median, IQR). accuracy evaluated across durations 10% (low),15% (moderate) 20% (high) thresholds. There 106,705 analyzed, 33.6% females an average 67.3±15.4 years old. density more frequent males than females, 66:34 respectively those older 65 age. (<10sec), 7 days, 13 days (Figure1). When comparing densities lower higher data showed decreased from 2.78% 3.97% 1.27% 1.75% Furthermore, categorization 15% threshold increased 89.2% 95.1% Most common concerning arrhythmias detected do show important delineating trend consider (Table1). In cohort, reduction through 14 underscores importance ambulatory extends prior results. Increased least 7-10 associated improved by level. <20% benefit longer compared >20% population. Concomitant arrythmias including VT Afib patient further emphasized closer early detection.Tabled 1Table1Total Device Count (%)Low (5%-10%)* n=59,702Moderate(10%-20%)* n=34,605High (>20%)* n=12,398Overall* n=106,705VT37,858 (63.4)23,799 (68.8)9,251 (74.6)70,908 (66.5)AFIB9,021 (15.1)4,123 (11.9)1,119 (9.0)14,263 (13.4)SVT46,068 (77.2)26,712 (77.2)9,495 (76.6)82,275 (77.1)AVB1,467 (2.5)671 (1.9)181 (1.5)2,319 (2.2)Pause (≥3 sec)3,479 (5.8)1,682 (4.9)466 (3.8)5,627 (5.3) Open table new tab